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cell lines mc38 ova mark smyth n a ct26 atcc  (ATCC)


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    ATCC cell lines mc38 ova mark smyth n a ct26 atcc
    A) Outline of experimental strategy. <t>CT26</t> colon carcinoma was used. B) Heatmap of the 3031 differentially expressed genes across the TILs subpopulations. Naïve: CD8+CD62LhiCD44low cells from non tumor-bearing Balb/c mice, EffMem: Effector memory CD8+CD62LlowCD44hi cells from non tumor-bearing Balb/c mice, DN: CD8+Tim3−PD1, SP: CD8+Tim3−PD1+, DP: CD8+Tim3+PD1+ TILs from CT26 colon carcinoma. C) Cluster 2 is significantly enriched with genes up-regulated in a CD8+ viral exhaustion signature (Doering et al., 2012) as well as an in vivo CD8+ activation signature (Sarkar et al., 2008). p-values determined by hypergeometric test. D) Heatmap of the top ranking genes from cluster 2. See also Suppl Fig 1 and Suppl tables 1 and 2.
    Cell Lines Mc38 Ova Mark Smyth N A Ct26 Atcc, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 3486 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cell lines mc38 ova mark smyth n a ct26 atcc/product/ATCC
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    1) Product Images from "A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells"

    Article Title: A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells

    Journal: Cell

    doi: 10.1016/j.cell.2016.08.052

    A) Outline of experimental strategy. CT26 colon carcinoma was used. B) Heatmap of the 3031 differentially expressed genes across the TILs subpopulations. Naïve: CD8+CD62LhiCD44low cells from non tumor-bearing Balb/c mice, EffMem: Effector memory CD8+CD62LlowCD44hi cells from non tumor-bearing Balb/c mice, DN: CD8+Tim3−PD1, SP: CD8+Tim3−PD1+, DP: CD8+Tim3+PD1+ TILs from CT26 colon carcinoma. C) Cluster 2 is significantly enriched with genes up-regulated in a CD8+ viral exhaustion signature (Doering et al., 2012) as well as an in vivo CD8+ activation signature (Sarkar et al., 2008). p-values determined by hypergeometric test. D) Heatmap of the top ranking genes from cluster 2. See also Suppl Fig 1 and Suppl tables 1 and 2.
    Figure Legend Snippet: A) Outline of experimental strategy. CT26 colon carcinoma was used. B) Heatmap of the 3031 differentially expressed genes across the TILs subpopulations. Naïve: CD8+CD62LhiCD44low cells from non tumor-bearing Balb/c mice, EffMem: Effector memory CD8+CD62LlowCD44hi cells from non tumor-bearing Balb/c mice, DN: CD8+Tim3−PD1, SP: CD8+Tim3−PD1+, DP: CD8+Tim3+PD1+ TILs from CT26 colon carcinoma. C) Cluster 2 is significantly enriched with genes up-regulated in a CD8+ viral exhaustion signature (Doering et al., 2012) as well as an in vivo CD8+ activation signature (Sarkar et al., 2008). p-values determined by hypergeometric test. D) Heatmap of the top ranking genes from cluster 2. See also Suppl Fig 1 and Suppl tables 1 and 2.

    Techniques Used: In Vivo, Activation Assay

    (A–B). Mice deficient in both MT1 and MT2 (MT−/−) and wild type (WT) littermate controls were implanted subcutaneously with B16F10 melanoma. A) Mean tumor growth. Statistical analysis was performed using linear regression ***p-value < 0.001. B) Tumor draining Lymph node (dLN, upper panel) and tumor-infiltrating lymphocytes (TIL, lower panel) were isolated from WT and MT−/− mice 15 days post tumor inoculation and stimulated with tumor antigen gp100. On day 3, tumor antigen-specific proliferation was measured by 3H incorporation. C) Naïve OT-1 cells were sorted, activated, and infected with empty retrovirus (control OT1) or MT1 retrovirus (MT OT1) prior to transfer (1 ×106 cells/mouse) into WT mice that were subsequently implanted with MC38-OVA tumor the next day. Mean tumor growth is shown. Statistical analysis was performed using linear regression **p-value < 0.01. D-E) MT−/− CD8+ TILs have increased functionality as compared to WT CD8+ TILs. TILs were isolated and stimulated with PMA/ionomyicin in the presence of brefeldin A for 4 hours prior to extracellular and intracellular staining and analysis by flow cytometry. *p-value < 0.05. F) Tim-3 and PD-1 expression in WT and MT−/− TILs. The DN, SP, and DP subpopulations are present in both the WT and MT−/− TILs. See also Suppl Fig 2.
    Figure Legend Snippet: (A–B). Mice deficient in both MT1 and MT2 (MT−/−) and wild type (WT) littermate controls were implanted subcutaneously with B16F10 melanoma. A) Mean tumor growth. Statistical analysis was performed using linear regression ***p-value < 0.001. B) Tumor draining Lymph node (dLN, upper panel) and tumor-infiltrating lymphocytes (TIL, lower panel) were isolated from WT and MT−/− mice 15 days post tumor inoculation and stimulated with tumor antigen gp100. On day 3, tumor antigen-specific proliferation was measured by 3H incorporation. C) Naïve OT-1 cells were sorted, activated, and infected with empty retrovirus (control OT1) or MT1 retrovirus (MT OT1) prior to transfer (1 ×106 cells/mouse) into WT mice that were subsequently implanted with MC38-OVA tumor the next day. Mean tumor growth is shown. Statistical analysis was performed using linear regression **p-value < 0.01. D-E) MT−/− CD8+ TILs have increased functionality as compared to WT CD8+ TILs. TILs were isolated and stimulated with PMA/ionomyicin in the presence of brefeldin A for 4 hours prior to extracellular and intracellular staining and analysis by flow cytometry. *p-value < 0.05. F) Tim-3 and PD-1 expression in WT and MT−/− TILs. The DN, SP, and DP subpopulations are present in both the WT and MT−/− TILs. See also Suppl Fig 2.

    Techniques Used: Isolation, Infection, Staining, Flow Cytometry, Expressing

    KEY RESOURCES TABLE
    Figure Legend Snippet: KEY RESOURCES TABLE

    Techniques Used: Generated, Recombinant, Sample Prep, Microarray, RNA Sequencing Assay, Sequencing, CRISPR, Software



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    cell lines mc38 ova mark smyth n a ct26 atcc  (ATCC)
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    ATCC cell lines mc38 ova mark smyth n a ct26 atcc
    A) Outline of experimental strategy. <t>CT26</t> colon carcinoma was used. B) Heatmap of the 3031 differentially expressed genes across the TILs subpopulations. Naïve: CD8+CD62LhiCD44low cells from non tumor-bearing Balb/c mice, EffMem: Effector memory CD8+CD62LlowCD44hi cells from non tumor-bearing Balb/c mice, DN: CD8+Tim3−PD1, SP: CD8+Tim3−PD1+, DP: CD8+Tim3+PD1+ TILs from CT26 colon carcinoma. C) Cluster 2 is significantly enriched with genes up-regulated in a CD8+ viral exhaustion signature (Doering et al., 2012) as well as an in vivo CD8+ activation signature (Sarkar et al., 2008). p-values determined by hypergeometric test. D) Heatmap of the top ranking genes from cluster 2. See also Suppl Fig 1 and Suppl tables 1 and 2.
    Cell Lines Mc38 Ova Mark Smyth N A Ct26 Atcc, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cell lines mc38 ova mark smyth n a ct26 atcc/product/ATCC
    Average 99 stars, based on 1 article reviews
    cell lines mc38 ova mark smyth n a ct26 atcc - by Bioz Stars, 2026-02
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    A) Outline of experimental strategy. CT26 colon carcinoma was used. B) Heatmap of the 3031 differentially expressed genes across the TILs subpopulations. Naïve: CD8+CD62LhiCD44low cells from non tumor-bearing Balb/c mice, EffMem: Effector memory CD8+CD62LlowCD44hi cells from non tumor-bearing Balb/c mice, DN: CD8+Tim3−PD1, SP: CD8+Tim3−PD1+, DP: CD8+Tim3+PD1+ TILs from CT26 colon carcinoma. C) Cluster 2 is significantly enriched with genes up-regulated in a CD8+ viral exhaustion signature (Doering et al., 2012) as well as an in vivo CD8+ activation signature (Sarkar et al., 2008). p-values determined by hypergeometric test. D) Heatmap of the top ranking genes from cluster 2. See also Suppl Fig 1 and Suppl tables 1 and 2.

    Journal: Cell

    Article Title: A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells

    doi: 10.1016/j.cell.2016.08.052

    Figure Lengend Snippet: A) Outline of experimental strategy. CT26 colon carcinoma was used. B) Heatmap of the 3031 differentially expressed genes across the TILs subpopulations. Naïve: CD8+CD62LhiCD44low cells from non tumor-bearing Balb/c mice, EffMem: Effector memory CD8+CD62LlowCD44hi cells from non tumor-bearing Balb/c mice, DN: CD8+Tim3−PD1, SP: CD8+Tim3−PD1+, DP: CD8+Tim3+PD1+ TILs from CT26 colon carcinoma. C) Cluster 2 is significantly enriched with genes up-regulated in a CD8+ viral exhaustion signature (Doering et al., 2012) as well as an in vivo CD8+ activation signature (Sarkar et al., 2008). p-values determined by hypergeometric test. D) Heatmap of the top ranking genes from cluster 2. See also Suppl Fig 1 and Suppl tables 1 and 2.

    Article Snippet: ​ REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Rat anti-PD-1 (clone: RMP1-30) Biolegend Cat#: 109109 Anti-Tim3 (clone: 5D12) Generated in house N/A Rat anti-IL-2 (clone: JES6-5H4) Biolegend Cat#: 503807 Anti-TNF-α (clone: MP6-XT22), eBioscience Cat#: 117321 Anti-IFN-γ (clone: XMG-1.2) Biolegend Cat# 505829 Mouse anti-Granzyme B (clone: GB11) Biolegend Cat#: 515405 Rat anti-CD8 (clone: 53–6.7) Biolegend Cat# 100731 Chemicals, Peptides, and Recombinant Proteins Zinpyr-1 Santa Cruz Cat#: sc-213182 Fixable viability dye eFluor506 eBioscience Cat#: 65-0866 Gp100 Genscript Cat#: RP20344 Critical Commercial Assays High Sensitivity DNA Kit (Bioanalyzer) Agilent Cat#: 5067-4626 Qubit dsDNA, High Sensitivity 500rxn Thermo Fisher Scientific Cat#: {"type":"entrez-protein","attrs":{"text":"Q32854","term_id":"75280861","term_text":"Q32854"}} Q32854 Nextera XT Sample Preparation Kit Illumina Cat#: FC-131-1096 NextSeq 500 high output kit V2, 75 cycles Illumina Cat#: FC-404-2005 Deposited Data Data files for CD8+ populations, Microarray This paper need to get accession number Data files for bulk RNA sequencing This paper need to get accession number Data files for single-cell RNA sequencing This paper need to get accession number LCMV exhaustion signature ( Doering et al., 2012 ) {"type":"entrez-geo","attrs":{"text":"GSE41867","term_id":"41867"}} GSE41867 CD8 + Ly49 + Treg signature ( Kim et al., 2015 ) {"type":"entrez-geo","attrs":{"text":"GSE73015","term_id":"73015"}} GSE73015 Experimental Models: Cell Lines MC38-OVA Mark Smyth N/A CT26 ATCC Cat#: CRL-2638 B16-F10 ATCC Cat#: CRL-6475 Experimental Models: Organisms/Strains Balb/c Jackson Laboratory Cat#: 000651 C57BL/6 Jackson Laboratory Cat#: 000664 PMEL Jackson Laboratory Cat#: 005023 OTI Jackson Laboratory Cat#: 003831 MT −/− (backcrossed to C57BL/6 in house) Jackson Laboratory Cat#: 002211 Recombinant DNA SMARTER TSO (with LNA, 10 µM)) Exiqon 5’- AAGCAGTGGTATC AACGCAGAGTACr GrG+G-3’ PCR oligonucleotide primer (10 µM) IDT 5’- AAGCAGTGGTATC AACGCAGAGT-3 Reverse Transcription DNA oligonucleotide primer (RNase-free, 100 µM) IDT 5- AAGCAGTGGTATC AACGCAGAGTACT (30)VN-3 Sequence-Based Reagents Gata3 CRISPR guide sequence Designed in house 5’ - GGTATCCTCCGAC CCACCACG Software and Algorithms GenePattern ( Reich et al., 2006 ) http://software.broadinstitute.org/cancer/software/genepattern/ COMBAT ( Johnson et al., 2007 ) http://www.bu.edu/jlab/wp-assets/ComBat/Download.html Bowtie ( Langmead et al., 2009 ) http://bowtie-bio.sourceforge.net/index.shtml RSEM ( Li and Dewey, 2011 ) http://deweylab.github.io/RSEM/ XL-mHG ( Wagner, 2015 ) https://github.com/flocompbio/xlmhg Other Open in a separate window KEY RESOURCES TABLE Distinct gene modules for T cell dysfunction and activation can be uncoupled.

    Techniques: In Vivo, Activation Assay

    (A–B). Mice deficient in both MT1 and MT2 (MT−/−) and wild type (WT) littermate controls were implanted subcutaneously with B16F10 melanoma. A) Mean tumor growth. Statistical analysis was performed using linear regression ***p-value < 0.001. B) Tumor draining Lymph node (dLN, upper panel) and tumor-infiltrating lymphocytes (TIL, lower panel) were isolated from WT and MT−/− mice 15 days post tumor inoculation and stimulated with tumor antigen gp100. On day 3, tumor antigen-specific proliferation was measured by 3H incorporation. C) Naïve OT-1 cells were sorted, activated, and infected with empty retrovirus (control OT1) or MT1 retrovirus (MT OT1) prior to transfer (1 ×106 cells/mouse) into WT mice that were subsequently implanted with MC38-OVA tumor the next day. Mean tumor growth is shown. Statistical analysis was performed using linear regression **p-value < 0.01. D-E) MT−/− CD8+ TILs have increased functionality as compared to WT CD8+ TILs. TILs were isolated and stimulated with PMA/ionomyicin in the presence of brefeldin A for 4 hours prior to extracellular and intracellular staining and analysis by flow cytometry. *p-value < 0.05. F) Tim-3 and PD-1 expression in WT and MT−/− TILs. The DN, SP, and DP subpopulations are present in both the WT and MT−/− TILs. See also Suppl Fig 2.

    Journal: Cell

    Article Title: A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells

    doi: 10.1016/j.cell.2016.08.052

    Figure Lengend Snippet: (A–B). Mice deficient in both MT1 and MT2 (MT−/−) and wild type (WT) littermate controls were implanted subcutaneously with B16F10 melanoma. A) Mean tumor growth. Statistical analysis was performed using linear regression ***p-value < 0.001. B) Tumor draining Lymph node (dLN, upper panel) and tumor-infiltrating lymphocytes (TIL, lower panel) were isolated from WT and MT−/− mice 15 days post tumor inoculation and stimulated with tumor antigen gp100. On day 3, tumor antigen-specific proliferation was measured by 3H incorporation. C) Naïve OT-1 cells were sorted, activated, and infected with empty retrovirus (control OT1) or MT1 retrovirus (MT OT1) prior to transfer (1 ×106 cells/mouse) into WT mice that were subsequently implanted with MC38-OVA tumor the next day. Mean tumor growth is shown. Statistical analysis was performed using linear regression **p-value < 0.01. D-E) MT−/− CD8+ TILs have increased functionality as compared to WT CD8+ TILs. TILs were isolated and stimulated with PMA/ionomyicin in the presence of brefeldin A for 4 hours prior to extracellular and intracellular staining and analysis by flow cytometry. *p-value < 0.05. F) Tim-3 and PD-1 expression in WT and MT−/− TILs. The DN, SP, and DP subpopulations are present in both the WT and MT−/− TILs. See also Suppl Fig 2.

    Article Snippet: ​ REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Rat anti-PD-1 (clone: RMP1-30) Biolegend Cat#: 109109 Anti-Tim3 (clone: 5D12) Generated in house N/A Rat anti-IL-2 (clone: JES6-5H4) Biolegend Cat#: 503807 Anti-TNF-α (clone: MP6-XT22), eBioscience Cat#: 117321 Anti-IFN-γ (clone: XMG-1.2) Biolegend Cat# 505829 Mouse anti-Granzyme B (clone: GB11) Biolegend Cat#: 515405 Rat anti-CD8 (clone: 53–6.7) Biolegend Cat# 100731 Chemicals, Peptides, and Recombinant Proteins Zinpyr-1 Santa Cruz Cat#: sc-213182 Fixable viability dye eFluor506 eBioscience Cat#: 65-0866 Gp100 Genscript Cat#: RP20344 Critical Commercial Assays High Sensitivity DNA Kit (Bioanalyzer) Agilent Cat#: 5067-4626 Qubit dsDNA, High Sensitivity 500rxn Thermo Fisher Scientific Cat#: {"type":"entrez-protein","attrs":{"text":"Q32854","term_id":"75280861","term_text":"Q32854"}} Q32854 Nextera XT Sample Preparation Kit Illumina Cat#: FC-131-1096 NextSeq 500 high output kit V2, 75 cycles Illumina Cat#: FC-404-2005 Deposited Data Data files for CD8+ populations, Microarray This paper need to get accession number Data files for bulk RNA sequencing This paper need to get accession number Data files for single-cell RNA sequencing This paper need to get accession number LCMV exhaustion signature ( Doering et al., 2012 ) {"type":"entrez-geo","attrs":{"text":"GSE41867","term_id":"41867"}} GSE41867 CD8 + Ly49 + Treg signature ( Kim et al., 2015 ) {"type":"entrez-geo","attrs":{"text":"GSE73015","term_id":"73015"}} GSE73015 Experimental Models: Cell Lines MC38-OVA Mark Smyth N/A CT26 ATCC Cat#: CRL-2638 B16-F10 ATCC Cat#: CRL-6475 Experimental Models: Organisms/Strains Balb/c Jackson Laboratory Cat#: 000651 C57BL/6 Jackson Laboratory Cat#: 000664 PMEL Jackson Laboratory Cat#: 005023 OTI Jackson Laboratory Cat#: 003831 MT −/− (backcrossed to C57BL/6 in house) Jackson Laboratory Cat#: 002211 Recombinant DNA SMARTER TSO (with LNA, 10 µM)) Exiqon 5’- AAGCAGTGGTATC AACGCAGAGTACr GrG+G-3’ PCR oligonucleotide primer (10 µM) IDT 5’- AAGCAGTGGTATC AACGCAGAGT-3 Reverse Transcription DNA oligonucleotide primer (RNase-free, 100 µM) IDT 5- AAGCAGTGGTATC AACGCAGAGTACT (30)VN-3 Sequence-Based Reagents Gata3 CRISPR guide sequence Designed in house 5’ - GGTATCCTCCGAC CCACCACG Software and Algorithms GenePattern ( Reich et al., 2006 ) http://software.broadinstitute.org/cancer/software/genepattern/ COMBAT ( Johnson et al., 2007 ) http://www.bu.edu/jlab/wp-assets/ComBat/Download.html Bowtie ( Langmead et al., 2009 ) http://bowtie-bio.sourceforge.net/index.shtml RSEM ( Li and Dewey, 2011 ) http://deweylab.github.io/RSEM/ XL-mHG ( Wagner, 2015 ) https://github.com/flocompbio/xlmhg Other Open in a separate window KEY RESOURCES TABLE Distinct gene modules for T cell dysfunction and activation can be uncoupled.

    Techniques: Isolation, Infection, Staining, Flow Cytometry, Expressing

    KEY RESOURCES TABLE

    Journal: Cell

    Article Title: A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells

    doi: 10.1016/j.cell.2016.08.052

    Figure Lengend Snippet: KEY RESOURCES TABLE

    Article Snippet: ​ REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Rat anti-PD-1 (clone: RMP1-30) Biolegend Cat#: 109109 Anti-Tim3 (clone: 5D12) Generated in house N/A Rat anti-IL-2 (clone: JES6-5H4) Biolegend Cat#: 503807 Anti-TNF-α (clone: MP6-XT22), eBioscience Cat#: 117321 Anti-IFN-γ (clone: XMG-1.2) Biolegend Cat# 505829 Mouse anti-Granzyme B (clone: GB11) Biolegend Cat#: 515405 Rat anti-CD8 (clone: 53–6.7) Biolegend Cat# 100731 Chemicals, Peptides, and Recombinant Proteins Zinpyr-1 Santa Cruz Cat#: sc-213182 Fixable viability dye eFluor506 eBioscience Cat#: 65-0866 Gp100 Genscript Cat#: RP20344 Critical Commercial Assays High Sensitivity DNA Kit (Bioanalyzer) Agilent Cat#: 5067-4626 Qubit dsDNA, High Sensitivity 500rxn Thermo Fisher Scientific Cat#: {"type":"entrez-protein","attrs":{"text":"Q32854","term_id":"75280861","term_text":"Q32854"}} Q32854 Nextera XT Sample Preparation Kit Illumina Cat#: FC-131-1096 NextSeq 500 high output kit V2, 75 cycles Illumina Cat#: FC-404-2005 Deposited Data Data files for CD8+ populations, Microarray This paper need to get accession number Data files for bulk RNA sequencing This paper need to get accession number Data files for single-cell RNA sequencing This paper need to get accession number LCMV exhaustion signature ( Doering et al., 2012 ) {"type":"entrez-geo","attrs":{"text":"GSE41867","term_id":"41867"}} GSE41867 CD8 + Ly49 + Treg signature ( Kim et al., 2015 ) {"type":"entrez-geo","attrs":{"text":"GSE73015","term_id":"73015"}} GSE73015 Experimental Models: Cell Lines MC38-OVA Mark Smyth N/A CT26 ATCC Cat#: CRL-2638 B16-F10 ATCC Cat#: CRL-6475 Experimental Models: Organisms/Strains Balb/c Jackson Laboratory Cat#: 000651 C57BL/6 Jackson Laboratory Cat#: 000664 PMEL Jackson Laboratory Cat#: 005023 OTI Jackson Laboratory Cat#: 003831 MT −/− (backcrossed to C57BL/6 in house) Jackson Laboratory Cat#: 002211 Recombinant DNA SMARTER TSO (with LNA, 10 µM)) Exiqon 5’- AAGCAGTGGTATC AACGCAGAGTACr GrG+G-3’ PCR oligonucleotide primer (10 µM) IDT 5’- AAGCAGTGGTATC AACGCAGAGT-3 Reverse Transcription DNA oligonucleotide primer (RNase-free, 100 µM) IDT 5- AAGCAGTGGTATC AACGCAGAGTACT (30)VN-3 Sequence-Based Reagents Gata3 CRISPR guide sequence Designed in house 5’ - GGTATCCTCCGAC CCACCACG Software and Algorithms GenePattern ( Reich et al., 2006 ) http://software.broadinstitute.org/cancer/software/genepattern/ COMBAT ( Johnson et al., 2007 ) http://www.bu.edu/jlab/wp-assets/ComBat/Download.html Bowtie ( Langmead et al., 2009 ) http://bowtie-bio.sourceforge.net/index.shtml RSEM ( Li and Dewey, 2011 ) http://deweylab.github.io/RSEM/ XL-mHG ( Wagner, 2015 ) https://github.com/flocompbio/xlmhg Other Open in a separate window KEY RESOURCES TABLE Distinct gene modules for T cell dysfunction and activation can be uncoupled.

    Techniques: Generated, Recombinant, Sample Prep, Microarray, RNA Sequencing Assay, Sequencing, CRISPR, Software